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This is a weekly feature that runs down the week鈥檚 top 10 announced funding rounds in the U.S. Check out last week鈥檚 biggest funding deal roundup here.

This week鈥檚 largest fundraising recipient was frontier AI lab , and agentic AI, AI-compute, and AI-native startups filled up much of the rest of the Top 10 list. Other areas that attracted sizable funding include biotech, nuclear power, and security.

1.听, $300M, AI: , a frontier AI lab, announced that it has raised $300 million in a Series A round of funding at a $4 billion valuation. led the latest round, which comes just two months after the Palo Alto, California-based company鈥檚 launch.

2.听, $257M, biotech: Cellares, a startup focused on the automated, large-scale manufacturing of cell therapies, said it secured $257 million in a Series D financing led by and . Founded in 2019, South San Francisco, California-based Cellares has raised $612 million to date.

3 (tied). , $250M, cloud security: Cloud security unicorn Upwind Security closed on $250 million in Series B funding led by . The round brings total investment for the San Francisco-headquartered company to over $430 million.聽

3 (tied). , $250M, AI agents: San Francisco-based Decagon, a developer of AI tools for customer service, raised for $250 million in new funding. and led the round, which tripled Decagon鈥檚 valuation to $4.5 billion in under six months.

5.听, $150M, AI compute: PaleBlueDot AI, an AI compute platform founded in 2024, announced that it completed a $150 million Series B financing, valuing the company at over $1 billion. led the financing for the Palo Alto, California-based company.聽

6.听, $140M, nuclear power: Oak Ridge, Tennessee-based Standard Nuclear, a provider of advanced nuclear fuel, raised $140 million in a Series A round led by and joined by a long list of new and existing investors. The company said it will use the financing to expand annual production to more than two metric tons by mid-2026.

7.听, $100M, space tech: Northwood Space, a startup focused on improving ground infrastructure for space missions, landed $100 million in Series B funding. and led the financing for the Southern California-based company, which was founded in 2023.

8 (tied).聽, $75M, agentic AI: Rogo, developer of an agentic AI system for financial workflows, raised $75 million in a Series C financing led by . The New York-based startup is also opening its first international office in London, with plans to expand into Europe.

8 (tied).聽, $75M, crypto payments: San Francisco-based crypto payments network Mesh picked up $75 million in Series C funding led by . Its platform enables consumers to make payments with a range of cryptocurrencies, with merchants receiving instant settlement in their preferred stablecoin.

10 (tied).聽, $60M, health insurance: Austin-based Gyde, an AI-native insurance brokerage platform, launched with $60 million in initial funding led by .听听

10 (tied).聽, $60M, biotech: Breakthru Medicine, a startup focused on therapies for cancer patients, emerged from stealth with $60 million in Series A financing.

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